One of the most positive advancements with the V35A powertrain is the 10AT vs the 6 or 8AT with the 5.7L V8. Shifts are shorter and much faster, and there are more gears, which all make a big difference with drivability and responsiveness. Transmission tuning with the 1UR-FE V8 was awfully slow and dull, though it did have the benefit of more linear throttle response from being N/A.
Something like a theoretical "2UR-FKS" with a 10AT could have probably been a great engine for LX, LS, LC, Land Cruiser, Tundra, etc. but the question becomes if it would have been significantly more capable or powerful than the V35A-FTS to create a viable business case? Is it really necessary? Feels like V8s would need turbos to make them make sense over the V35A in most applications. 409-415hp and 442-479lb-ft is pretty close to what I would expect a "2UR-FKS" to put down... so what's the point? V35A is already there, plus more efficient and compact.
I do think V35A-FTS is a great engine for 90% of buyers who aren't dipping into the throttle often and frustrated with turbo lag, especially after they fixed the rough idle issue. Lexus should let their hair down a bit with F SPORT or potential FSP models that have sportier transmission tuning and richer tunes. For example, why can't LS 500 and LX 600 F SPORT have 450hp and 500lb-ft of torque? That's not asking for much at all.
I think the issue is that Lexus considers the V35A a flagship engine when it's really just a mid-tier powerplant compared to the competition which all have V8s, turbo V8s, PHEV systems or pure EVs. It's just down on power and let's be honest, that matters when you're spending $80k+.