In North America, V6 is going to be most important for 4Runner, Tacoma, Highlander, Sienna, base Tundra, RX, GX... passenger cars are probably going to get it just to share costs, at least maybe for one more generation. I can see a good turbocharged 4 cylinder being fine in Camry, Avalon and ES, but those shopping for heavier vehicles that can tow and haul will certainly be looking for a V6.
Still to this day, 2GR-FKS is such a good engine that it's hard to beat for N/A reliability, smoothness, MPG and power. We are months away from 300HP V6 with Dynamic Torque Vectoring AWD on ES/Camry/Avalon. Hard to argue with that for day-to-day driving, even for enthusiasts.
The only cars that are really asking for more than 300hp are heavy 4Runner, Tacoma, RX and GX.